Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics

NJ Camp; LA Cannon-Albright; JM Farnham; AB Baffoe-Bonnie; A George; I Powell; JE Bailey-Wilson; JD Carpten; GG Giles; JL Hopper; G Severi; DR English; WD Foulkes; L Maehle; P Moller; R Eeles; D Easton; MD Badzioch; AS Whittemore; I Oakley-Girvan; CL Hsieh; L Dimitrov; J Xu; JL Stanford; B Johanneson; K Deutsch; L McIntosh; EA Ostrander; KE Wiley; SD Isaacs; PC Walsh; SN Thibodeau; SK McDonnell; S Hebbring; DJ Schaid; EM Lange; KA Cooney; TLJ Tammela; J Schleutker; T Paiss; C Maier; H Grönberg; F Wiklund; M Emanuelsson; WB Isaacs

Journal article

Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics

NJ Camp, LA Cannon-Albright, JM Farnham, AB Baffoe-Bonnie, A George, I Powell, JE Bailey-Wilson, JD Carpten, GG Giles, JL Hopper, G Severi, DR English, WD Foulkes, L Maehle, P Moller, R Eeles, D Easton, MD Badzioch, AS Whittemore, I Oakley-Girvan Show all

Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2007

DOI: 10.1093/hmg/ddm075

Abstract

Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12.3-13.1 (flanked on each side by three recombinants) contained 31 annotated genes. In this large, multi-centered, collaborative study, we performed statistical recombinant mapping in 54 pedigrees selected to be informative for recombinant mapping from nine member groups of the International Consortium for Prostate Cancer Genetics (ICPCG). These 54 pedigrees included the 14 extended pedigrees from Utah and 40 pedigrees from eight other ICPCG member groups. The additional 40 pedigrees were selected from a total pool of 1213 such that each pedigree was required to co..

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